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Classification of protein kinases
Die Proteinkinasen werden anhand ihrer Aminosäuresequenz in verschiedene Untergruppen eingeteilt. Die in den Untergruppen vertretenen Enzyme haben meist ähnliche Spezifitäten für die zu modifizierenden Zielproteine und sind häufig auch sehr ähnlich in der Art und Weise, wie sie reguliert werden. Desweiteren gibt es in den Untergruppen auch sehr grosse strukturelle Ähnlichkeiten.
Die folgende Einteilung beruht auf einer classification by Steve Hanks :
serine-/threonin protein kinases
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AGC group I
cAMP- and cGMP-dependent protein kinases (PKA, PKG)
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AGC group VI
PKs phosphorylating ribosomal proteins of the S6 family (S6K, RSK)
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AGC group II
diacylglycerol- and phospholipid-dependent protein kinases (PKC)
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AGC group VII
DBF2/20 family of yeast
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AGC group III
RAC/Akt (PKB)
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AGC group VIII
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AGC group IV
PKs phosphorylating G-protein coupled receptors (GRK, ARK)
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AGC group further
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AGC group V
AGC-related PKs from yeast
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CaMK group I
calcium/calmodulin-dependent PKs
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CaMK group II
calcium/calmodulin-dependent PKs
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CaMK group weitere
further related CaM-dependent PKs
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CMGC group I
cyclin-dependent protein kinases and related protein kinases
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CMGC group VI
casein kinase II family
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CMGC group II
ERK (MAP) kinase family
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CMGC group V
Clk family
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CMGC group III
glycogen-synthase kinase3 family (GSK3)
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CMGC group weitere
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tyrosine protein kinases
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PTK group I
(Src, Yes, Fyn, Hck, Lck)
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PTK group VI
(Syk, ZAP70)
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PTK group II
(Tec, Atk)
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PTK group VII
(Tyk, Jak)
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PTK group III
(Csk)
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PTK group VIII
(Ack)
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PTK group IV
(Fes, Fps)
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PTK group IX
focal adhesion Kinase (FAK)
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PTK group V
(Abl)
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PTK group X
epidermis growth factor receptors (EGFR)
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PTK group XVII
(LTK, ALK)
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PTK group XI
(Eph, Elk, Eck)
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PTK group XVIII
(Ros, Sevenless)
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PTK group XII
(Axl)
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PTK group XIX
(Trk, Ror)
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PTK group XIII
(Tie, Tek)
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PTK group XX
(DDR, TKT)
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PTK group XIV
“Platelet-derived” growth factor receptors (PDGF-R)
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PTK group XXI
hepatocyte growth factor receptors
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PTK group XV
fibroblast growth factor receptors (FGFR)
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PTK group XXII
(Kin15/16)
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PTK group XVI
insulin receptors
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PTK andere transmembrane Kinasen
(Ret, Nyk)
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